A Look into Intravenous Immunoglobulin (IVIG) Industry……Deep Analysis…..



Global intravenous immunoglobulin market is expected to reach USD 10.9 billion by 2022, according to a new study by Grand View Research, Inc.
Multiple therapeutic regimens are being followed across the globe in attempts to come up with a reliable treatment for Covid-19. One line of treatment includes the use of hydroxychloroquine, while a second treatment line focuses to use antiviral drugs used in the disease management of HIV. Both these approaches have surged demand from advanced antivirals and antimalarial drugs. This impacts the drug manufacturers as an off label indication for these drug classes has to be worked upon. At the moment, the WHO has not prescribed any of these approaches, neither they have commented if one is better than the other. The report will account for Covid19 as a key market contributor.
The increasing prevalence of immunodeficiency diseases coupled with the adoption of IVIG therapies is expected to fuel market growth over the forecast period. In addition, increasing off-label use of immunoglobulin and investments in the healthcare sector are factors propelling market growth. Moreover, increasing incidences of bleeding disorders and rising geriatric population base are the factors attributing towards the industry growth.
The rising incorporation of subcutaneous immunoglobulin in the treatment of primary immunodeficiency diseases and in replacement therapy is anticipated to provide growth platform to the immunoglobulin market in the next seven years.
The global immunoglobulin industry is consolidated in nature and a limited number of players have a high level of dominance over the global revenue share. The key players are Biotest AG, Baxter International Inc., Octapharma AG, LFB Biotechnologies, Grifols SA, CSL Behring, China Biologics Products Inc., Kedrion Biopharma, and BDI Pharma Inc.
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The global intravenous immunoglobulin (IVIG) market size was estimated at USD 9.09 billion in 2016 and is anticipated to grow at a CAGR of 7.1% over the forecast period. Growing geriatric population, rising prevalence of immunodeficiency diseases, increasing adoption of IVIG treatments and rising use of off-label indications are the key drivers of the market. Rising number of patients with immunodeficiency disorders is the primary cause for the development of IVIG preparations.
Further key findings from the study suggest:
·         Increasing demand for immunoglobulin replacement therapies to treat hypogammaglobulinemia diseases is driven by rising awareness levels amongst patients and increasing incidences of the disease. This has attributed towards hypogammaglobulinemia diseases segment’s dominant market share in 2014
·         The U.S. National library of Medicine and the National Institute of Health published a report, which states that in 2012, about 6 million patients suffered from PID (Primary immunodeficiency Diseases) globally and is expected to grow further, representing the potential growth for the treatment of hypogammaglobulinemia in the coming years
·         The Kawasaki disease market segment is expected to grow at a rapid pace with a lucrative CAGR of over 8.0% from 2015 to 2022 owing to the massive adoption of IVIG treatment in the aforementioned disease management
·         Intravenous route of administration is most commonly used in the treatment of autoimmune diseases and accounted for the largest market share in 2014. Subcutaneous administration is anticipated to be growing at a lucrative CAGR of over 9.0% during the forecast period. This can be attributed to the associated potential advantages such as fewer side effects and shorter response time with subcutaneous route of administration and rising preference for subcutaneous home-based self-infusion
·         North America held the largest regional market share in terms of revenue in 2014 due to the presence of a well-regulated healthcare system, the larger pool of target population, and high patient awareness pertinent to the plasma protein products
·         The European intravenous immunoglobulin market is expected to show an impressive CAGR at above 6.0% over the forecast period owing to the increasing number of patients with bleeding disorders and growing number of CIDP patients
·         Countries such as India, China, and South Africa are expected to show significant growth over the forecast period owing to improving healthcare facilities, rising healthcare expenditure, and growing public awareness of immune deficiency disorders
·         Chinese IVIG market is poised to show a growth rate of over 7.0% owing to the presence of major market players such as China Biologics Products, Inc. facilitating the industry growth
·         Some key players of IVIG industry are Biotest AG, Octapharma AG, China Biologics Products Ltd., Baxter international, Inc., CSL Limited, LFB group and Grifols S.A.
·         These key players are adopting strategic alliances to sustain the competition. These initiatives include mergers & acquisitions, collaborations, and new product developments.
·         For instance, in January 2016, Biotest AG entered into a collaborative agreement with Kedrion Pharma to expand the distribution capabilities of Bivigam. This was carried out to improve production facility utilization and manage idle capacity costs enabling better optimization.
According to the W.H.O, currently, there are over 50 different Primary Immune Deficiency (PID’s) such as specific antibody deficiency, X-lined hypo-gamma-globulinemia, and others. PIDs include 176 different types of rare hereditary disorders. According to the U.S. National Library of Medicine and National Institute of Health, approximately 6 million patients are suffering from PID worldwide. Growing incidences of these diseases is expected to boost the demand for immunoglobulin therapies over the forecast period.
The demand for IVIG therapies for the treatment of acquired and primary immunodeficiency diseases is increasing as it is the most effective & the only available treatment option. Moreover, sedentary lifestyle habits, including consumption of saturated fats salt, & sugars, less physical activities, and high alcohol consumption have led to the increase in the prevalence of these diseases.Rising prevalence of lifestyle associated disorders such as obesity & antibody deficiency disorders are the factors expected to drive the growth.
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The global geriatric population base is on a rise. According to a report published by United States Census Bureau, the number of people aged 65 and older in the U.S. was approximately 46.2 million in 2014 and is expected to reach over 98 million by 2060. Aging also weakens immune systems and consequently heightens a patient’s susceptibility towards acquiring infectious diseases. The global base of geriatric population is expected to grow over the next few years is expected to serve this industry as a high impact rendering driver.
Grand View Research has segmented the global intravenous immunoglobulin market on the basis of application and region: 
Global Intravenous Immunoglobulin Market Application Outlook (Revenue, USD Million, 2012 - 2022)
·         Hypogammaglobulinemia
·         CIPD
·         Immunodeficiency diseases
·         Congenital AIDS
·         Chronic Lymphocytic Leukemia
·         Myasthenia Gravis
·         Multifocal motor neuropathy
·         ITP
·         Kawasaki disease
·         Guillain-Barre syndrome
·         Others
Global Immunoglobulin Market Route of Administration Outlook (Revenue, USD Million, 2012 - 2022)
·         Intravenous
·         Subcutaneous
About Grand View Research
Grand View Research, Inc. is a U.S. based market research and consulting company, registered in the State of California and headquartered in San Francisco. The company provides syndicated research reports, customized research reports, and consulting services. To help clients make informed business decisions, we offer market intelligence studies ensuring relevant and fact-based research across a range of industries, from technology to chemicals, materials and healthcare.



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